Integrating large-scale neuroimaging research datasets: harmonisation of white matter hyperintensity measurements across Whitehall and UK Biobank datasets

Bordin, V., Bertani, I., Mattioli, I., Sundaresan, V., McCarthy, P., Suri, S., Zsoldos, E., Filippini, N., Mahmood, A., Melazzini, L., Laganà, M. M., Zamboni, G., Singh-Manoux, A., Kivimäki, M., Ebmeier, K. P., Baselli, G., Jenkinson, M., Mackay, C. E., Duff, E. P., Griffanti L. (2020). Integrating large-scale neuroimaging research datasets: harmonisation of white matter hyperintensity measurements across Whitehall and UK Biobank datasets. bioRxiv.

https://doi.org/10.1101/2020.07.28.208579​​​​​​​

Abstract

Large scale neuroimaging datasets present the possibility of providing normative distributions for a widevariety of neuroimaging markers, which would vastly improve the clinical utility of these measures. However, a major challenge is our current poor ability to integrate measures across  different  large-scale  datasets,  due  to inconsistencies  inimaging  and  non-imaging measures across the different protocols and populations. Here we explore the harmonisation of white matter hyperintensity (WMH) measures across two major studies of healthy elderly populations,  the  Whitehall  II  imaging  sub-study  and the UK  Biobank.  We  identify  pre-processing strategies that maximise the consistency across datasets and utilise multivariate regression to characterise sample differences contributing to study-level differences in WMH variations.  We  also  present  a  parser  to  harmonise  WMH-relevant  non-imaging  variables across the two datasets. We show that we can provide highly calibrated WMH measures from these datasets with:(1)the inclusion of a number of specific standardised processing steps;and (2)appropriate modelling of sample differences through the alignment of demographic, cognitive and physiological variables. These results open up a widerange of applications for the  study  of WMHs and other  neuroimaging  markers  across  extensive  databases of  clinical data

Tags: Harmonisation, MRI, white matter hyperintensities, UK Biobank
Published Aug. 12, 2020 2:45 PM - Last modified Aug. 12, 2020 2:45 PM