Association of cerebral small vessel disease burden with brain structure and cognitive and vascular risk trajectories in mid-to-late life

Michelle G Jansen, Ludovica Griffanti, Clare E Mackay, Melis Anatürk, Luca Melazzini, Ann-Marie G de Lange, Nicola Filippini, Enikő Zsoldos, Kim Wiegertjes, Frank-Erik de Leeuw, Archana Singh-Manoux, Mika Kivimäki, Klaus P Ebmeier, Sana Suri

Preprint May 2021


We characterize the associations of total cerebral small vessel disease (SVD) burden with brain structure, trajectories of vascular risk factors, and cognitive functions in mid-to-late life. Participants were 623 community-dwelling adults from the Whitehall II Imaging Sub-study with multi-modal MRI (mean age 69.96 SD=5.18, 79% men). We used linear mixed-effects models to investigate associations of SVD burden with up to 25-year retrospective trajectories of vascular risk and cognitive performance. General linear modelling was used to investigate concurrent associations with grey matter (GM) density and white matter (WM) microstructure, and whether these associations were modified by cognitive status (Montreal Cognitive Assessment, MoCA). Severe SVD burden in older age was associated with higher mean arterial pressure throughout midlife (β=3.36, 95% CI [0.42-6.30]), and faster 25-year cognitive decline in letter fluency (β=-0.07, 95% CI [-0.13–-0.01]), and verbal reasoning (β=-0.05, 95% CI [-0.11–-0.001]). Moreover, SVD burden was related to lower GM volumes in 9.7% of total GM, and widespread WM microstructural decline (FWE-corrected p<0.05). The latter association was most pronounced in individuals with cognitive impairments on MoCA (F3,608=2.14, p=0.007). These findings highlight the importance of managing midlife vascular health to preserve brain structure and cognitive function in old age.

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Published May 21, 2021 9:32 AM - Last modified May 21, 2021 9:32 AM